1. Proportions required for a primary emulsion (oil, water & gum respectively).
3. Containers used for aerosols should withstand a pressure of 140– 180 Psig at 130°F.
4. The HLB requirement for the detergency is about 13 to 16.
5. Lactose should not be used for the preparation of tablets for amine-containing basic drugs because of lactose reacts with such drugs via a set of reactions (Maillard reaction which includes condensation – amine/carbonyl, Amadori
rearrangement, fragmentation) and cause browning of the product. Anhydrous lactose does not show Maillard reaction. All reducing sugars, e.g. glucose, galactose, maltose, maltodextrines, undergo Maillard reaction with compounds containing primary amino-groups, peptides and proteins.
6. General terms used for expressing solubility
Term – Parts of solvent required to dissolve 1 part of solute
- Fixed oils 4:2:1
- Volatile oils 2:2:1
- Mineral oils 3:2:1
- Oleo-resins 1:2:1
3. Containers used for aerosols should withstand a pressure of 140– 180 Psig at 130°F.
4. The HLB requirement for the detergency is about 13 to 16.
5. Lactose should not be used for the preparation of tablets for amine-containing basic drugs because of lactose reacts with such drugs via a set of reactions (Maillard reaction which includes condensation – amine/carbonyl, Amadori
rearrangement, fragmentation) and cause browning of the product. Anhydrous lactose does not show Maillard reaction. All reducing sugars, e.g. glucose, galactose, maltose, maltodextrines, undergo Maillard reaction with compounds containing primary amino-groups, peptides and proteins.
6. General terms used for expressing solubility
Term – Parts of solvent required to dissolve 1 part of solute
- Very soluble – Less than 1 part
- Freely soluble – 1 to 10 parts
- Soluble – 10 to 30 parts
- Sparingly soluble – 30 to 100 parts
- Slightly soluble – 100 to 1000 parts
- Very slightly soluble – 1000 to 10,000 parts
- Practically insoluble – More than 10,000 parts
- Teaspoonful = 4ml
- Dessertspoonful = 8ml
- Tablespoonful = 15ml
- Store in a cool place - Store between 8-25 °C
- Cold - Temperature not exceeding 8 °C, usually between 2-8 °C
- Cool - Any temperature between 8-25 °C. alternatively, it can be stored in between 2- 8 °C in refrigeration
- Room temperature - Temperature of the working area
- Excessive heat - Any temperature above 40 °C
- Storage under Non -specific conditions - Storage under protection from moisture, freezing and excessive heat
Capsule No. and Their Approximate Capacity in mg and ml
Capsule Size
|
mg
|
ml
|
000 (Largest)
|
950
|
1.37
|
00
|
650
|
0.95
|
0
|
450
|
0.68
|
1
|
300
|
0.50
|
2
|
250
|
0.37
|
3
|
200
|
0.30
|
4
|
150
|
0.21
|
5 (Smallest)
|
100
|
0.13
|
Proportions required for a primary emulsion
Type of Oil
|
Oil: Water: Gum Ratio
|
Fixed Oils
|
4:2:1
|
Mineral Oils
|
3:2:1
|
Volatile Oils
|
2:2:1
|
Oleoresins
|
1:2:1
|
The easy trick to remember surfactant
CODE: LPSO (Apply This for Spans & Tweens)
For example-
SPANS 20 Means Sorbitan Mono Laurate
TWEEN 80 Means Polyoxyethylene Sorbitan Monooleate
- L: Laurate - 20
- P: Palmitate - 40
- S: Stearate - 60
- O: Oleate - 80
The angle of repose and flow character
25 – 30 - Excellent
31 – 35 - Good
36 – 40 - Fair
41 – 45 - Passable
46 – 55 - Poor
56 – 65 - Very Poor
More than 66 - Very Very Poor
