Saturday, 30 December 2017

Pharmacognosy Notes for GPAT Preparation

Crude Medicine, Biological Source, Family, Chemical Constituents and Uses.

Tobacco

Pyridine-piperidine alkaloid.
Dried leaves of Nicotiana tobacum, Solanaceae.
Constituents - Pyridine-piperidine type alkaloids like Nicotine. Nornicotine & anabasine.
Use - Stimulant effect on heart & nervous system, tobacco & nicotine are known insecticides.

Belladonna

Tropane alkaloid.
Dried leaves & flowering tops of Atropa belladonna, Solanaceae.
Constituents Atropine, l-hyoscyamine, scopolamine, hyoscine, belladonine, scopoletin.
Use -Anticholinergic, antispasmodic, Antisecretory, mydriasis effect, CNS stimulant. Antimuscarinic agent, used as antidote in opium & chloral hydrate poisoning.

Hyoscyamus

Tropane alkaloid.
Dried leaf & flowering top of Hyoscyamus niger, Solanaceae.
Constituents  - l-hyoscyamine, hyoscine.
Use -Anticholinergic , antispasmodic, expectorant, antiasthmatic.

Datura herb

Tropane alkaloid.
Dried leaves & flowering tops of Datura metel var. fastuosa, Datura alba, Solanaceae.
Constituents  -Hyoscine (Scopolamine), l-hyoscyamine (scopoline), atropine.
Use -Anticholinergic, in duodenal ulcers, in treatment of asthma & cough.

Coca

Tropane alkaloid.
Dried leaves of Erythroxylon coca, Erythroxylon truxillense, Erythroxylaceae.
Constituents  -Cocaine, cinnamyl-cocaine, α-truxilline.
Use - Local anesthetic.

Withania (Ashwagandha)

Steroidal alkaloid.
Dried roots of Withania somnifera, Solanaceae.
Constituents  -Withanine, somniferine, withanolide (steroid), somnine, somnferinine, anahydrine.
Use - Sedative & also as antirheumatic, it has hypotensive, respiratory, stimulant actions along with bradycardia.

Cinchona

Quinoline alkaloid.
Dried root/stem bark of Cinchona calisaya, C. officinalis, C. ledgeriana, C. succirubra, Rubiaceae.
Constituents  -Quinine, quinidine, cinchonine, cinchonidine.
Use - Antimalarial, bitter tonic.

Ipecac

Isoquinoline alkaloid.
Roots & rhizomes of Cephaelis ipecacuanha & C. acuminata, Rubiaceae.
Constituents  -Emetine, cephaeline.
Use - Antiamoebic, emetic, expectorant.

Opium

Isoquinoline alkaloid.
Dried latex from the capsules of Papaver somniferum, Papaveraceae.
Constituents  -Morphine, codeine, narcotine (noscapine) and papaverine,  thevaine.
Use - Narcotic analgesic, in diarrhea Codeine as antitussive Ergot.

Indole alkaloid

A fungal sclerotium of Claviceps purpurea in ovary of rye plant Secale cereale.
Family of fungus-Clavicipitaceae, family of rye Graminae.
Constituents  -Ergometrine, ergotamine, ergosterol, fungisterol, histamine, tyramine, chitin.
Use - Oxytocic, prevents postpartum haemorrhage; used in treat of migraine.

Rauwolfia

Indole alkaloid.
Roots & rhizomes of Rauwolfia serpentina, Apocynaceae.
Constituents  - Reserpine, rescinnamine, ajmaline, ajmalicine, rauwolfinine, reserpinine, yohimbine, serpentine, serpentinine.
Use - Hypotensive, tranquilliser, antihypertensive, used in mild anxiety condition.

Vinca

Indole alkaloid
Entire plant of Catharanthus roseus, Apocynaceae.
Constituents  -Vincristine, vinblastine, ajmalicine, lochnerine, serpentine, tetrahydroalstonine.
Use -Anticancer (treat of hodgkin’s disease & leukemia), also exhibits hypotensive & antidiabetic actions.

Nuxvomica

Indole alkaloid.
Seeds of Strychnos nux vomica Linn., Loganiaceae.
Constituents  -Strychnine, brucine, vomicine, α-colubrine, strychnicine, pseudostrychnine.
Use - CNS stimulant, bitter, stomachic, tonic, Very toxic plant, appetite stimulant in small doses.

Physostigma

Indole alkaloid.
Seeds of Physostigma venonosum, Loganiaceae or leguminosae.
Constituents - Physostigmine, physovenine, eseramine, geneserine, calabatine, calabasine.
Use - Cholinergic, (opthalmic) in glaucoma, anticholinesterase agent.

Pilocarpus

Imidazole alkaloid.
Leaves of the closely related plant of the genus Pilocarpus like Pilocarpus jaborandi, Rutaceae.
Constituents  -Pilocarpine, isopilocarpine, pilocarpidine, pilosine.
Use - It is a physiological antagonist of atropine, used in ophthalmic practice for the treatment of glaucoma.

Veratrum

Steroidal alkaloids.
Dried rhizomes of Veratrum album & V. viride, Liliaceae.
Constituents  -Germidine, protoveratrine A & B, veratrine, germitrine, cevadine, pseudojervijne, veratrosine.
Use - Hypotensive, cardiac depressant.

Kurchi

Steroidal alkaloids.
Dried bark of Holarrhena antidysenterica, Apocynaceae.
Constituents - Conessine, isoconessine, norconessine, dioxyconessine, connessimine, holarrhimine.
Use - Antiamoebic, antiprotozoal activity.

Ephedra

Amino alkaloid (Proto-alkaloid).
Dried stems of Ephedra gerardiana, E. equisetina, E. sinica etc., Gnetaceae (Ephedraceae).
Constituents  -Ephedrine, nor-ephedrine, pseudoephedrine (alkaloidal amines).
Use - Sympathomimetic, antiasthmatic, treat of hay fever, as bronchodilator in asthma.

Solanum khasianum

Steroidal glyco alkaloid.
Dried berries of solanum khasianum C.B. Clarke, Solanaceae.
Constituents  -Solasodine.
Use - Solasodine is used as a precursor for steroidal synthesis. It is related to sex hormones, oral contraceptives.

Tea

Purine alkaloid.
Leaves & leaf buds of Thea sinensis, Theaceae.
Constituents - Caffeine, theobromine, theoromine, theophylline.
Use - CNS stimulant & diuretic.

Colchicum

Amino alkaloid (Proto-alkaloid).
Seed & corm of Colchicum autumnale, Colchicum luteum Baker, Liliaceae.
Constituents  -Colchicine, Demecolcine.
Use - Treat of gout, induction of polyploidy, also posses antitumour activity.

Coffee

Purine alkaloid.
Dried ripe seeds of Coffea Arabica, Rubiaceae.
Constituents  -Caffeine, trigonelline.
Use - Stimulant & diuretic action, to counter effect over dosage of CNS depressant.

Aconite

Amino alkaloid (Proto-alkaloid).
Dried roots of Aconitum napellus, Aconitum ferox, Ranunculaceae.
Constituents - Aconitine, neopelline, hypaconitine, napelline, neoline.
Use - It is highly poisonous drug. Used externally in treat of neuralgia, rheumatism, sciatica & inflammation.