Pharmacy MCQ Questions - Set 8.
1. For glyburide, all of the following metabolic reactions are logical EXCEPT.
A. O-demethylation.
B. Aromatic oxidation.
C. Benzylic hydroxylation.
D. Amide hydrolysis.
2. The effects observed following systemic administration of levodopa in the treatment of Parkinsonism have been attributed to its catabolism to dopamine. Carbidopa can markedly increase the proportion of levodopa that crosses the blood-brain barrier by.
A. Increasing penetration of levodopa through BBB by complexation with it.
B. Decreasing peripheral metabolism of levodopa.
C. Decreasing metabolism of levodopa in the CNS.
D. Decreasing clearance of levodopa from the CNS.
3. Ethambutol molecule has.
A. Two chiral centres and 3 stereoisomers.
B. Two chiral centres and 4 stereoisomers.
C. Two chiral centres and 2 stereoisomers.
D. One chiral centre and 2 stereoisomers.
4. A compound will be sensitive towards IR radiation only when one of the following properties undergo transition on.
A. Polarizability.
B. Dielectric constant.
C. Dipole moment.
D. Refractivity.
5. X-ray crystallographic analysis of an optically active compound determines its.
A. Optical rotatory dispersive power.
B. Absolute configuration.
C. Relative configuration.
D. Optical purity.
6. Which one of the following statements is WRONG?
A. A singlet or triplet state may result when one of the electrons from the HOMO is excited to higher energy levels.
B. In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the electron in the ground state orbital.
C. Triplet excited state is more stable than the singlet excited state.
D. When the electron from the singlet excited state returns to ground state, the molecule always shows fluorescence phenomenon.
7. Aminotransferases usually require the following for their activity.
A. Niacinamide.
B. Vitamin B12.
C. Pyridoxal phosphate.
D. Thiamine.
8. The purity of water can be assessed by determining one of its following properties instrumentally.
A. pH.
B. Refractivity.
C. Viscosity.
D. Conductivity.
9. Which one of the following statements is WRONG?
A. Carbon NMR is less sensitive than proton NMR.
B. 12C nucleus is not magnetically active.
C. Both 13C and *H have same spin quantum numbers.
D. The gyromagnetic ratio of *H is lesser than that of 1 C.
10. In the TCA cycle, at which of the following enzyme-catalyzed steps, incorporation of elements of water into an intermediate of the cycle takes place.
A. Citrate synthase.
B. Aconitase.
C. Maleate dehydrogenase.
D. Succinyl Co-A synthase.
11. Humectants added in cosmetic preparations generally act by.
A. Hydrogen bond formation.
B. Covalent bond formation.
C. Complex formation.
D. The action of London forces.
12. In the mixing of thymol and menthol, the following type of incompatibility occurs.
A. Chemical incompatibility.
B. Therapeutic incompatibility.
C. Physical incompatibility.
D. Tolerance incompatibility.
13. Bloom strength is used to check the quality of.
A. Lactose.
B. Ampoules.
C. Hardness of tablets.
D. Gelatin.
14. The characteristic of non-linear pharmacokinetics include.
A. The area under the curve is proportional to the dose.
B. Elimination half-life remains constant.
C. The area under the curve is not proportional to the dose.
D. Amount of drug excreted through remains constant.
15. In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is.
A. Schedule M.
B. Schedule C.
C. Schedule Y.
D. Schedule H.
2. Decreasing peripheral metabolism of levodopa.
3. Two chiral centres and 4 stereoisomers.
4. Dipole moment.
5. Absolute configuration.
6. Triplet excited state is more stable than the singlet excited state.
7. Pyridoxal phosphate.
8. Conductivity.
9. The gyromagnetic ratio of *H is lesser than that of 1 C.
10. Maleate dehydrogenase.
11. Hydrogen bond formation.
12. Physical incompatibility.
13. Gelatin.
14. Area under the curve is not proportional to the dose.
15. Schedule M.
A. O-demethylation.
B. Aromatic oxidation.
C. Benzylic hydroxylation.
D. Amide hydrolysis.
2. The effects observed following systemic administration of levodopa in the treatment of Parkinsonism have been attributed to its catabolism to dopamine. Carbidopa can markedly increase the proportion of levodopa that crosses the blood-brain barrier by.
A. Increasing penetration of levodopa through BBB by complexation with it.
B. Decreasing peripheral metabolism of levodopa.
C. Decreasing metabolism of levodopa in the CNS.
D. Decreasing clearance of levodopa from the CNS.
3. Ethambutol molecule has.
A. Two chiral centres and 3 stereoisomers.
B. Two chiral centres and 4 stereoisomers.
C. Two chiral centres and 2 stereoisomers.
D. One chiral centre and 2 stereoisomers.
4. A compound will be sensitive towards IR radiation only when one of the following properties undergo transition on.
A. Polarizability.
B. Dielectric constant.
C. Dipole moment.
D. Refractivity.
5. X-ray crystallographic analysis of an optically active compound determines its.
A. Optical rotatory dispersive power.
B. Absolute configuration.
C. Relative configuration.
D. Optical purity.
6. Which one of the following statements is WRONG?
A. A singlet or triplet state may result when one of the electrons from the HOMO is excited to higher energy levels.
B. In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the electron in the ground state orbital.
C. Triplet excited state is more stable than the singlet excited state.
D. When the electron from the singlet excited state returns to ground state, the molecule always shows fluorescence phenomenon.
7. Aminotransferases usually require the following for their activity.
A. Niacinamide.
B. Vitamin B12.
C. Pyridoxal phosphate.
D. Thiamine.
8. The purity of water can be assessed by determining one of its following properties instrumentally.
A. pH.
B. Refractivity.
C. Viscosity.
D. Conductivity.
9. Which one of the following statements is WRONG?
A. Carbon NMR is less sensitive than proton NMR.
B. 12C nucleus is not magnetically active.
C. Both 13C and *H have same spin quantum numbers.
D. The gyromagnetic ratio of *H is lesser than that of 1 C.
10. In the TCA cycle, at which of the following enzyme-catalyzed steps, incorporation of elements of water into an intermediate of the cycle takes place.
A. Citrate synthase.
B. Aconitase.
C. Maleate dehydrogenase.
D. Succinyl Co-A synthase.
11. Humectants added in cosmetic preparations generally act by.
A. Hydrogen bond formation.
B. Covalent bond formation.
C. Complex formation.
D. The action of London forces.
12. In the mixing of thymol and menthol, the following type of incompatibility occurs.
A. Chemical incompatibility.
B. Therapeutic incompatibility.
C. Physical incompatibility.
D. Tolerance incompatibility.
13. Bloom strength is used to check the quality of.
A. Lactose.
B. Ampoules.
C. Hardness of tablets.
D. Gelatin.
14. The characteristic of non-linear pharmacokinetics include.
A. The area under the curve is proportional to the dose.
B. Elimination half-life remains constant.
C. The area under the curve is not proportional to the dose.
D. Amount of drug excreted through remains constant.
15. In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is.
A. Schedule M.
B. Schedule C.
C. Schedule Y.
D. Schedule H.
Answers
1. Aromatic oxidation.2. Decreasing peripheral metabolism of levodopa.
3. Two chiral centres and 4 stereoisomers.
4. Dipole moment.
5. Absolute configuration.
6. Triplet excited state is more stable than the singlet excited state.
7. Pyridoxal phosphate.
8. Conductivity.
9. The gyromagnetic ratio of *H is lesser than that of 1 C.
10. Maleate dehydrogenase.
11. Hydrogen bond formation.
12. Physical incompatibility.
13. Gelatin.
14. Area under the curve is not proportional to the dose.
15. Schedule M.
