Pharmacy MCQ Questions and Answers - Set 23

Pharmacy MCQ Questions - Set 23.

1. Which of the following respective Phase-I and Phase-II reactions are the most common drug biotransformation reactions?

A. Oxidation and Glucuronidation.

B. Reduction and Acetylation.

C. Hydrolysis and Glucuronidation.

D. Oxidation and Glutathion conjugation.

2. Which one of the following drugs has positive inotropic and negative chronotropic action?

A. Dopamine.

B. Epinephrine.

C. Digoxin.

D. Isoprenaline.

3. Which one of the following therapeutic classes has been proved clinically as a first line therapy for heart failure and has shown decreased hospitalization, improved symptoms and delayed disease progression?

A. Cardiac glycosides.

B. ACE Inhibitors (ACEIs).

C. Renin Antagonists.

D. Nitrites.

4. Which one of the following glucose transporters is the new drug target for the management of Type-2 diabetes mellitus?

A. Sodium glucose linked transporter-2 (SGLT2).

B. Glucose transporter-1 (GLUTl).

C. Sodium glucose linked transporter-1 (SGLTl).

D. Glucose transporter-2 (GLUT2).

5. Which one of the following modes of HIV transmission carries the highest relative risk of infection with the single exposure?

A. Transfusion of blood and blood products.

B. Perinatal - from mother to child.

C. Sexual contacts with infected partners.

D. Syringe sharing with drug addicts.

6. Which of the followings are the critical neurotransmitters playing a major role in depression?

A. Acetylcholine, Norepinephrine and Dopamine.

B. Dopamine, Norepinephrine and Serotonin.

C. Serotonin, Dopamine and y-Aminobutyric acid.

D. Acetylcholine, Serotonin and y-Aminobutyric acid.

7. A 55 years old man is under DOTS treatment for pulmonary tuberculosis for the last four months. Now, he has developed symptoms of peripheral neuritis. Choose the right addition to this therapy to manage the peripheral neuritis?

A. Cyanocobalamin.

B. α-Lipoic acid.

C.   Pyridoxine.

D. Prednisolone.

[In that we asked about which of the following drug given to "TB patient" to reduce the peripheral neuritis side effect of ANTI TB drugs].

8. What is the primary mechanism of action of local anaesthetics?

A. Activation of ligand-gated potassium channels.

B. Blockade of voltage-gated sodium channels.

C. Stimulation of voltage-gated N-type calcium channels.

D. Blockade of GABA-gated chloride channels.

9. Which one of the following anti-asthmatic drugs can cause convulsions and arrhythmia?

A. Prednisolone.

B. Salmeterol.

C. Zafirlukast.

D. Theophylline.

10. Which one of the following anti-arrhythmic drug act through inhibiting K, Na and Ca channels?

A. Quinidine.

B. Lignocaine.

C. Amiodarone.

D. Flecainide.

11. A forty-eight years old woman is having the symptoms of weight gain, constipation, cold intolerance, puffy face, bradycardia, dry skin, and lethargy. These symptoms are suggestive of which of the followings?

A. Overuse of corticosteroid.

B. Hypothyroidism.

C. Estrogen deficiency.

D. Overuse of thyroxin sodium.

12. Increased risk of hypoglycemia and weight gain is the common side effect of drugs that are used in the management of Type-II diabetes mellitus. Followings are some commonly used drugs, alone or in the combination, for the management of Type-II diabetes mellitus.

[P]: Metformin [Q]: Pioglitazone [R]: Glipizide [S]: Sitagliptin.

Choose the correct combination of drugs which is without risk of hypoglycemia and weight neutral.

A. P and Q.

B. Q and R.

C. R and S.

D. P and S.

13. Which one of the following receptors is NOT a ligand-gated ion channel receptor?

A. Nicotinic Receptor.

B. 5HT₃ - Receptor.

C. GABA_A – Receptor.

D. H₂ – Receptor.

14. Which one of the following classes of drugs cause side effects like dryness of mouth, tachycardia, urinary retention, constipation, blurring of vision, precipitation of glaucoma, drowsiness and impairment of cognition?

A. Anti-adrenergic.

B. Anti-cholinergic.

C. Anti-serotonergic.

D. Anti-dopaminergic.

15. Which of the following cytokines are the most important regulators in inflammation and are the targets for anti-inflammatory agents used in rheumatoid arthritis?

A. Tumor necrosis factor-a and Interleukin-1.

B. Acetylcholine esterase and Eicosanoids.

C. Leukotrienes and Isoprostanes.

D. Adhesion factor and Monoamine oxidase A.

Answers

1. Oxidation and Glucuronidation.

2. Digoxin.

3. ACE Inhibitors (ACEIs).

4. Sodium-glucose linked transporter-2 (SGLT2).

5. Transfusion of blood and blood products.

6. Dopamine, Norepinephrine and Serotonin.

7.  Pyridoxine.

8. Blockade of voltage-gated sodium channels.

9. Theophylline.

10. Amiodarone.

11. Hypothyroidism.

12. P and S.

13. H₂ – Receptor.

14. Anti-cholinergic.

15. Tumor necrosis factor-a and Interleukin-1.